CDC, Friday 18th June, Review potential link between heart inflammation and mRNA vaccines
https://www.medscape.com/viewarticle/952905?src=wnl_edit_tpal&uac=127834AR&impID=3435883&faf=1
https://www.cdc.gov/vaccines/acip/meetings/downloads/agenda-archive/agenda-2021-06-18-508.pdf
COVID-19 mRNA vaccines in adolescents and young adults: benefit-risk discussion
Discussion
CDC’s Advisory Committee on Immunization Practices
CDC, identified 216 cases of heart inflammation after 1st dose
Another 573 cases after the second shot
172 million people, at least one shot (789)
One in 217, 997
https://www.fda.gov/media/150054/download
Under 30 years, n = 475
285 with known disposition
15 still in hospital
3 ICU
270 discharged
180 (81%) full recovery
41 (19%) ongoing signs or unknown status
Myocarditis in over 12s
Presence of one, new or worsening
Chest pain pressure discomfort
Dyspnea SOB pain with breathing
Palpitations
ECG changes
Troponins
Abnormal cardiac function
Pericarditis
Acute chest pain
Pericardial rub
New ST elevation or PR depression
New or worsening pericardial effusion
CDC safety expert Tom Shimabukuro
We’re still learning about the rates of myocarditis and pericarditis
As we gather more information we’ll begin to get a better idea of the post-vaccination rates
and hopefully be able to get more detailed information by age group
Mr Biden
https://www.bbc.co.uk/news/uk-57436535
Confirmed 500 million doses of Pfizer
92 low and middle-income countries and the African Union
Manufactured from August
Mr Biden
The United States is providing these half billion doses with no strings attached.
Our vaccine donations don’t include pressure for favours, or potential concessions.
We’re doing this to save lives.
G 7s another 500 million
UK, 100 million
Five million doses by the end of September
25 million more by the end of the year
Federal regulators
Johnson & Johnson vaccine by six weeks, up to 4.5 months
https://www.washingtonpost.com/health/2021/06/11/fda-releases-johnson-johnson-vaccine-from-emergent-plant/
60 million doses to be discarded
South Africa implications
Chile
Population 19 million
https://www.washingtonpost.com/nation/2021/06/11/coronavirus-covid-live-updates-us/
Santiago going into full lockdown from tomorrow
Fully vaccinated, 58%
At least one dose, 75%
Cases, + 7,700
Hospitals crowded
ICU at 98%
Jose Luis Espinoza, Chile’s National Federation of Nursing Associations
Members were on the verge of collapse
Chinese-made CoronaVac vaccine
20 million vaccine doses administered
15.8 million, CoronaVac vaccine
3.6 million Pfizer-BioNTech
A few Oxford-AstraZeneca
Health Ministry, Wednesday and Thursday, 27% of cases were in fully vaccinated
74% under the age of 49
April, University of Chile
CoronaVac, 56% effective two weeks after second dose
Pandemic fatigue, travel, variants
https://www.nature.com/articles/d41586-021-01497-8
The World Health Organization (1st June) approved CoronaVac at 51% effective at preventing COVID-19 (in late-stage trials)
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3822780
HCWs in Brazil
100% effective at preventing severe disease and death
600 million doses have been delivered
(Sinopharm, efficacy of 79% against symptomatic disease)
PHE Delta viral assessment
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/992981/10_June_2021_Risk_assessment_for_SARS-CoV-2_variant_DELTA.pdf
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