Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
https://link.springer.com/article/10.1007/s00392-022-02129-5#Sec3
Likelihood assessment of vaccine-induced
(epi-)myocarditis
Causality or correlation?
Presence of myocarditis with temporal association to vaccination event
AND
Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis
Abstract infographic
Cases of myocarditis
Have been diagnosed clinically,
by laboratory tests,
imaging
(in the context of mRNA-based anti-SARS-CoV-2 vaccination)
Autopsy-based description
We describe,
Cardiac autopsy findings and common characteristics of myocarditis,
with vaccine-induced myocardial inflammation representing the likely or possible cause of death.
Our findings establish the histological phenotype of lethal vaccination-associated myocarditis.
Standardized autopsies
Performed on 25 persons
25 bodies found unexpectedly dead at home,
within 20 days following SARS-CoV-2 vaccination
Histology
Patchy, focal, interstitial myocardial T-lymphocytic and macrophage
infiltration,
predominantly of the CD4 positive sub- set, (T Helper cells)
associated with mild myocyte damage.
Autopsy findings indicated
Death due to acute arrhythmogenic cardiac failure.
Thus
Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination.
Our findings may aid in adequately diagnosing unclear cases after vaccination,
and in establishing a timely diagnosis in vivo, thus,
providing the framework for adequate monitoring and early treatment of severe clinical cases.
Source
In medical education, it can attempt to explain complex concepts, generating case scenarios, and can be used by students who are preparing for licensing examinations. ChatGPT can be used to summarize medical journal articles for researchers. The hallucinations characteristic of LLMs pose particular danger in medical contexts. ChatGPT can produce correct answers to medical exam and licensing questions, for example the United States Medical Licensing Examination and the Specialty Certificate Examination in Dermatology. It can also pass exams for medical licensing, for example the United States Medical Licensing Examination and the Specialty Certificate Examination in Dermatology.
In November 2023, OpenAI released GPT Builder a tool for users to customize ChatGPT’s behavior for a specific use case. ChatGPT’s Mandarin Chinese abilities were lauded, but the ability of the AI to produce content in Mandarin Chinese in a Taiwanese accent was found to be “less than ideal” due to differences between mainland Mandarin Chinese and Taiwanese Mandarin. However, no machine translation services match human expert performance. ChatGPT (based on GPT-4) was better able to translate Japanese to English when compared to Bing, Bard, and DeepL Translator in 2023. In 2023, OpenAI worked with a team of 40 Icelandic volunteers to fine-tune ChatGPT’s Icelandic conversation skills as a part of Iceland’s attempts to preserve the Icelandic language.
It was capable of autonomously performing tasks through web browser interactions, including filling forms, placing online orders, scheduling appointments, and other browser-based tasks. These include, among many others, writing and debugging computer programs, composing music, scripts, fairy tales, and essays, answering questions (sometimes at a level exceeding that of an average human test-taker), and generating business concepts. It is designed to generate human-like text and can carry out a wide variety of tasks. ChatGPT’s training data includes software manual pages, information about internet phenomena such as bulletin board systems, multiple programming languages, and the text of Wikipedia.
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