Fever threshold
https://covid.joinzoe.com/post/fever-and-temperature
https://www.medrxiv.org/content/10.1101/2021.01.26.21250480v1
Uninfected volunteers (twins), n = 1,089
Hospitalised, n = 1,227
Community based positives, n = 3,972
Results
Among unaffected volunteers
Lower BMI (p=0.001), and older age (p less than 0.001) associated with lower basal temperature
Basal temperature showed a heritability of 47%
In COVID-19+ participants
Increasing age associated with lower temperatures (p less than 0.001)
For each additional year of age, participants were 1% less likely to demonstrate a fever
Ageing affects temperature in health and acute infection
Older people with COVID-19 were also less likely to have a fever reaching 37.8°C
Current health guidelines, 37.8°C or more should self-isolate
Using a threshold of 37.4°C for over 65s is as sensitive and specific a sign of infection as 37.8°C in adults under 65
Global vaccine tracker
https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/
UK vaccine tracker
https://coronavirus.data.gov.uk/details/vaccinations
US vaccine tracker
https://covid.cdc.gov/covid-data-tracker/#vaccinations
Europe vaccine tracker
https://data.spectator.co.uk/city/vaccines
More vaccines for UK
https://www.bbc.co.uk/news/health-55887264
Valneva, an extra 40 million doses, now 100million
French, manufactured in Scotland
Available late 2021, and into 2022
Flexibility
Two doses, dead virus
Fridge storage
Nadhim Zahawi, any surplus vaccine could be distributed globally
South Africa variant in Surrey
https://www.bbc.co.uk/news/health-55889391
No known links to South Africa
Identified, Public Health England’s random checks
Surge testing, door to door testing, London, Kent, Hertfordshire, Walsall
US, Francis Collins, (National Institutes of Health)
We’re very worried
All it’s going to take is a couple more mutations on top of that, and you’re really going to have to start worrying
Novavax trial, Previous infection did not provide full immunity to B.1.351
https://www.novavax.com/covid-19-coronavirus-vaccine-candidate-updates
Efficacy against old strain = 95.6%
Efficacy against UK variant = 85.6%
Efficacy against SA variant = 60%
United Kingdom, South Africa, Brazil all in US
U.K. variant, B.1.1.7, 430 cases
Brazil variant, P.1., Minnesota
Jay Butler, Centers for Disease Control and Prevention
If a more transmissible strain becomes dominant, herd immunity, 80 to 85 %
Marc Lipsitch, Harvard, School of Public Health
We will not be for decades dealing with a pandemic
The concern is whether it will be a year or three years until we can make enough vaccines against enough strains to get this under control
Israel
https://www.theguardian.com/world/live/2021/feb/01/coronavirus-live-news-eu-wants-70-of-adults-vaccinated-by-end-of-summer-israel-extends-covid-lockdown
Population, 9,053,000
Vaccinated, 54% (19.7% completed)
Extends lockdown, started 27 December
Airports and borders closed
Persistent violations among ultra-Orthodox
Thousands pack into funeral, 31st January
Vaccinations complete end of March
Japan
https://www.washingtonpost.com/world/asia_pacific/japan-vaccine-delay-coronavirus/2021/01/30/a0b66322-5fd6-11eb-a177-7765f29a9524_story.html
Vaccines are an essential part of national security (2016 report)
Has not yet started vaccination
(Australia and South Korea)
Japanese vaccine, start-up AnGes in Osaka
Phase III trials, late 2021
Own tests for imported vaccines
Moderna vaccine trial began on Jan. 21, n = 200 people
Finishes March 11
Approval, May
50 million doses ordered
Oxford Astra Zeneca
Approval, late February
90 million manufactured in country
Olympics in July
Vaccinations for over 65s, April
Portugal
Population, 10.2 million
https://www.theguardian.com/world/live/2021/feb/01/coronavirus-live-news-eu-wants-70-of-adults-vaccinated-by-end-of-summer-israel-extends-covid-lockdown
UK variant and relaxation of restrictions over Christmas
The country had largely been spared by the first waves of the virus.
Deaths, January, 5,576 = 12,482
Hospitals, close to being overwhelmed
Santa Maria hospital, extra cold containers
Mental health in the Pandemic
Guernsey
Dance festival, 19 – 22 January
Mass spreader event, 186 cases
Now locked down
French warehouse, libertine party
https://www.dailymail.co.uk/news/article-9204555/Police-break-French-warehouse-orgy-involving-100-people.html
100 arrested
Collegien, Paris
Everyone else under curfew
Philadelphia
https://www.washingtonpost.com/nation/2021/01/27/philly-fighting-covid-vaccine/
Assigned duties to unskilled young adults
Start-up Philly Fighting COVID
Largest coronavirus mass vaccination site
Appointments not honoured
For profit
Sale of personal data
Provisions that would allow Philly Fighting COVID to sell users’ personal data to a third party
Unskilled people vaccinating each other
Source