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Merck, Pfizer COVID-19 Antivirals Different From Ivermectin. Link for Richard,
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SciCheck Digest

The pills are very different from the antiparasitic medication ivermectin,

Dubbed PF-07321332, the investigational medication is a protease inhibitor that blocks a key enzyme the SARS-CoV-2 virus needs to replicate itself.

Molnupiravir

While the results have not been published or peer-reviewed, they were compelling enough for the trial’s independent Data Monitoring Committee to recommend an early halt to recruitment into the study.

Food and Drug Administration, an advisory committee to discuss the application on Nov. 30.

Molnupiravir is a nucleoside analog — a drug that messes up viral replication by tricking the virus into using the processed medication as one of its building blocks for its genetic code.

This is what’s known as “error catastrophe,” using a mechanism called “lethal mutagenesis.”

Although both drugs are novel, with news of these developments, people on social media are spreading the false notion that the pills are the same or “suspiciously similar” to ivermectin

Some iterations of the claim incorrectly posit that Pfizer’s drug is “based on” ivermectin and that the two are essentially the same because both are protease inhibitors

— something that has not been established, and even if true, doesn’t mean the drugs are similar,

That paper, (computational modeling paper published by some Indian scientists in March)

however, does not show that ivermectin acts as a protease inhibitor against SARS-CoV-2 through any sort of biological experiment — it only proposes the possibility based on computer simulations.

Drugs Shown to Inhibit SARS-CoV-2 in COVID-19
Open Access

Disease: Comparative Basic and Clinical Pharmacology of
Molnupiravir and Ivermectin

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf

It (ivermectin) is being repurposed as a therapeutic agent for COVID-19, after in vitro studies in Vero/hSLAM cells, showed that it caused a 5000-fold inhibition of SARS-CoV-2,

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article (Journal of antibiotics)

http://dhakes.com/wp-content/uploads/2021/08/20210615-The-mechanisms-of-action-of-Ivermectin-against-SARS-CoV-2-An-evidence-based-clinical-review-article.pdf

One such enzyme, 3 chymotrypsin-like proteases (3’cl pro/ Mpro) is responsible for working on this polyprotein causing other proteins to “librate” and carry out viral replication. Ivermectin binds to this enzyme and disrupts it.

But the same is true of PF-07321332

Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations (20th August 2021)

https://pubmed.ncbi.nlm.nih.gov/34502033/

The crystal structure of 3CLpro in complex with PF-07321332, lopinavir, and ritonavir is not yet available. Therefore, the docked complex of PF-07321332, lopinavir, and ritonavir with 3CLpro was generated using the Molecular operating environment (MOE) software.

FB post

“Looks like Merck is repackaging the ‘horse drug’ and making it much more expensive! It will be the ‘new’ treatment for C. in pill form,”

The Food and Drug Administration has warned people against self-medicating with easier-to-access formulations of ivermectin for livestock, which are highly concentrated and also may include other ingredients that have not been tested in people.

As a result, there is no basis for claiming that either the Pfizer or Merck drugs are similar to ivermectin in any way.

Pfizer also denies any connection. “Pfizer’s protease inhibitor is not similar to that of an animal medicine and is not the same mechanism,” a company spokesperson said in an email

That post uses the phrase “Pfizermectin,”

Editor’s note: SciCheck’s COVID-19/Vaccination Project is made possible by a grant from the Robert Wood Johnson Foundation.

Final fact
Fluvoxamine also has 3 fluorine atoms as does PF-07321332

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